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Investigation of inflammatory memory in hematopoietic stem cells within the acute myeloid leukemia (AML) niche
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Investigation of inflammatory memory in hematopoietic stem cells within the acute myeloid leukemia (AML) niche

A new research perspective was published in from Oncotarget Volume 15 of September 4, 2024, titled “Trained and ready: the case for an inflammatory memory for hematopoietic stem and progenitor cells in the AML niche.”

As noted in the abstract of this article, lifelong hematopoiesis is supported by the interaction between hematopoietic stem and progenitor cells (HSPCs) and specialized niches in the bone marrow. Acute myeloid leukemia (AML) disrupts this balance, as leukemic blasts secrete factors that remodel the bone marrow into a self-reinforcing leukemic niche. Furthermore, HSPCs are key components of the innate immune system. Over the past decade, elegant studies of experimental infections and inflammation have demonstrated the generation of an adoptively transferable innate immune memory.

In their research perspective, Ding-Wen Chen, Eric K. Wafula, and Peter Kurre of the Department of Pediatrics, Comprehensive Bone Marrow Failure Center, Division of Hematology, and the Department of Biomedical and Health Informatics at the Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania discuss their laboratory’s recent findings on the active role of HSPCs in AML and its potential implications.

“Considering the abundant evidence of inflammation associated with AML and the involvement of healthy HSPCs analyzed in our study, the question arises whether sterile inflammation associated with cancer also has long-term functional consequences.”

Fountain:

Journal reference:

Chen, D.-W., and others(2024) Trained and ready: the case of an inflammatory memory for hematopoietic stem and progenitor cells in the acute myeloid leukemia (AML) niche. Oncological target. doi.org/10.18632/oncotarget.28642.

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